The aims were (1) to evaluate the location of INPH-related structural abnormalities of the lateral ventricles and (2) to investigate ...SkiptomaincontentThankyouforvisitingnature.com.YouareusingabrowserversionwithlimitedsupportforCSS.Toobtainthebestexperience,werecommendyouuseamoreuptodatebrowser(orturnoffcompatibilitymodeinInternetExplorer).Inthemeantime,toensurecontinuedsupport,wearedisplayingthesitewithoutstylesandJavaScript.AdvertisementnaturescientificreportsarticlesarticleLateralVentricleEnlargementandCorticalThinninginIdiopathicNormal-pressureHydrocephalusPatientsDownloadPDFSubjectsDiagnosticmarkersHydrocephalusNeurodegenerativediseasesAbstractWeutilizedthree-dimensional,surface-based,morphometricanalysistoinvestigateventricleshapebetween2groups:(1)idiopathicnormal-pressurehydrocephalus(INPH)patientswhohadapositiveresponsetothecerebrospinalfluidtaptest(CSFTT)and(2)healthycontrols.Theaimswere(1)toevaluatethelocationofINPH-relatedstructuralabnormalitiesofthelateralventriclesand(2)toinvestigaterelationshipsbetweenlateralventricularenlargementandcorticalthinninginINPHpatients.Thirty-threeINPHpatientsand23healthycontrolswereincludedinthisstudy.Weusedsparsecanonicalcorrelationanalysistoshowcorrelatedregionsofventricularsurfaceexpansionandcorticalthinning.SignificantsurfaceexpansionintheINPHgroupwasobservedmainlyinclustersbilaterallylocatedinthesuperiorportionofthelateralventricles,adjacenttothehighconvexityofthefrontalandparietalregions.INPHpatientsshowedasignificantbilateralexpansionofboththetemporalhornsofthelateralventriclesandthemedialaspectsofthefrontalhornsofthelateralventriclestosurroundingbrainregions,includingthemedialfrontallobe.Ventricularsurfaceexpansionwasassociatedwithcorticalthinninginthebilateralorbitofrontalcortex,bilateralrostralanteriorcingulatecortex,leftparahippocampalcortex,lefttemporalpole,rightinsula,rightinferiortemporalcortex,andrightfusiformgyrus.TheseresultssuggestthatpatientswithINPHhaveuniquepatternsofventricularsurfaceexpansion.Ourfin