Thus, the ability of the host to regulate the movement of T cells into the gut-associated lymphoid tissue (GALT), mesenteric lymph nodes (MLNs), and gut is of ...NCBISkiptomaincontentSkiptonavigationResourcesHowToAboutNCBIAccesskeysMyNCBISignintoNCBISignOutJournalListHHSAuthorManuscriptsPMC3075575AnnNYAcadSci.Authormanuscript;availableinPMC2011Oct1.Publishedinfinaleditedformas:AnnNYAcadSci.2010Oct;1207(Suppl1):E86–E93.doi: 10.1111/j.1749-6632.2010.05711.xPMCID:PMC3075575NIHMSID:NIHMS280222PMID:20961311Gut-associatedlymphoidtissue,Tcelltrafficking,andchronicintestinalinflammationIuriiKoboziev,FridrikKarlsson,andMatthewB.GrishamAuthorinformationCopyrightandLicenseinformationDisclaimerImmunologyandInflammationResearchGroup,DepartmentofMolecularandCellularPhysiology,LouisianaStateUniversityHealthSciencesCenter,Shreveport,LouisianaAddressforcorrespondence:MatthewB.Grisham,Ph.D.,ImmunologyandInflammationResearchGroup,DepartmentofMolecularandCellularPhysiology,LSUHealthSciencesCenter,1501KingsHighway,Shreveport,LA71130.ude.cshusl@hsirgmCopyrightnoticeThepublisher'sfinaleditedversionofthisarticleisavailableatAnnNYAcadSciSeeotherarticlesinPMCthatcitethepublishedarticle.Theetiologiesoftheinflammatoryboweldiseases(IBD;Crohn’sdisease,ulcerativecolitis)havenotbeenfullyelucidated.However,thereisverygoodevidenceimplicatingTcellandTcelltraffickingtothegutanditsassociatedlymphoidtissueasimportantcomponentsindiseasepathogenesis.TheobjectiveofthisreviewistoprovideanoverviewofthemechanismsinvolvedinnaiveandeffectorTcelltraffickingtothegut-associatedlymphoidtissue(GALT;Peyer’spatches,isolatedlymphoidfollicles),mesentericlymphnodesandintestineinresponsetocommensalentericantigensunderphysiologicalconditionsaswellasduringtheinductionofchronicgutinflammation.Inaddition,recentdatasuggeststhattheGALTmaynotberequiredforentericantigen-drivenintestinalinflammationincertainmousemodelsofIBD.ThesenewdatasuggestapossibleparadigmshiftinourunderstandingofhowandwherenaiveTcellsbecomeactivatedtoyielddis